The best replacement for flat ad is armor pen runes.

The best alternatives to flat ad are rated as following:
★★★★★  armor pen runes
★★★★  scaling ad
★★★★  arpen
★★★★  armor pen marks
★★  lifesteal
★★  armour pen
★★  ad per level
★  armor penetration
★  armor pen

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flat ad
armor pen runes
scaling ad