The best replacement for fallout new vegas is fallout 3.

The best alternatives to fallout new vegas are rated as following:
★★★★★  fallout 3
★★★  skyrim
★★★  fable 3
★★★  oblivion
★★  mass effect 2
★  borderlands
★  borderlands 2
★  red dead redemption
★  fallout 2
★  mass effect 3
  dead space 2
  bioshock 2
  halo reach
  dishonored
  fallout
  ac brotherhood
  assassin's creed brotherhood
  two worlds 2

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Speaking about fallout new vegas, one probably shouldn't forget about graphics mods.

Other search terms related to fallout new vegas and their ratings are:
★★★★★ graphics mods
★★★★ controller
★★ dead money
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