The best replacement for drug is dragged.

The best alternatives to drug are rated as following:
★★★★★  dragged
★★  medicine
★  pokemon
★  supplement
★  biologic
★  cosmetic
★  drug
★  medication
★  device fda
  ghostbusters
  narcotic
  drag
  placebo
  herb
  device
  vicodin
  codeine
  non formulary drug
  narrow spectrum drug
  bath salts
  food
  cir
  large molecule drug
  free drug

Your alternative for drug is not listed? Suggest!
Speaking about drug, one probably shouldn't forget about best high.

Other search terms related to drug and their ratings are:
★★★★★ best high
antidote
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Google Trends

Scale is based on the average worldwide traffic of drug in all years. Click on graph for more.
drug
dragged
medicine