The best replacement for diphenoxylate is lomotil.

The best alternatives to diphenoxylate are rated as following:
★★★★★  lomotil
★★★  loperamide

Your alternative for diphenoxylate is not listed? Suggest!
Speaking about diphenoxylate, one probably shouldn't forget about atropine.

Other search terms related to diphenoxylate and their ratings are:
★★★★★ atropine
You have in mind a companion for diphenoxylate and it is not yet here? Propose!



Google Trends

Scale is based on the average worldwide traffic of diphenoxylate in all years. Click on graph for more.
diphenoxylate
lomotil
loperamide