The best replacement for despite is in spite of.

The best alternatives to despite are rated as following:
★★★★★  in spite of
★★★★  although
★★★★  despite of
★★★★  in spite
★★★  inspite
★★★  in spite of grammar
★★  even though
★★  to spite
★★  regardless
★  notwithstanding
★  despise
★  inspite of
  in spite grammar
  spite
  in spite of define

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despite
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