The best replacement for depressant is antidepressant.

The best alternatives to depressant are rated as following:
★★★★★  antidepressant
★★  stimulant
★  hallucinogen
★  anti anxiety
  cns stimulant
  suppressant
  sedative

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No companions for depressant have been suggested so far.
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Google Trends

Scale is based on the average worldwide traffic of depressant in all years. Click on graph for more.
depressant
antidepressant
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