The best replacement for computer information systems is computer science.

The best alternatives to computer information systems are rated as following:
★★★★★  computer science
★★★  information technology
★★  computer engineering
★★  management information systems
★  accounting
★  information systems
  computer engineering technology
  computer information science
  computer information technology

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Google Trends

Scale is based on the average worldwide traffic of computer information systems in all years. Click on graph for more.
computer information systems
computer science
information technology