The best replacement for assassination is subtlety.

The best alternatives to assassination are rated as following:
★★★★★  subtlety
★★★  combat 5.4
★★★  combat rogue
★★  subtlety 5.4
★★  murder
★★  subtlety pvp
★★  combat
★  execution
★  killing
★  sub 5.4
★  lincoln assassination
★  targeted killing
★  combat pve
  combat for pve
  combat 4.3
  kennedy assassination
  sub pvp
  combat dps
  combat cataclysm
  richard nixon
  franz ferdinand
  subtlety rogue

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assassination
subtlety
combat 5.4