The best replacement for american cheese is cheddar cheese.

The best alternatives to american cheese are rated as following:
★★★★★  cheddar cheese
★★★★★  velveeta
★★★★★  swiss cheese
★★★★  cheddar
★★★★  provolone
★★★  real cheese
★★★  european cheese
★★★  kraft singles
★★★  mozzarella
★★  pepper jack
★  yellow american cheese
★  british cheese
★  yellow
★  white american cheese
  american cheese
  canadian cheese
  french cheese
  swiss
  provolone cheese

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Google Trends

Scale is based on the average worldwide traffic of american cheese in all years. Click on graph for more.
american cheese
cheddar cheese
velveeta