The best replacement for alpha centauri is civ 5.

The best alternatives to alpha centauri are rated as following:
★★★★★  civ 5
★★★★  civ 4
★★★  civ 2
★★★  civilization
★★★  civ
★★  proxima centauri
★  master of orion
★  master of orion 2
★  alien crossfire
★  galactic civilizations

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alpha centauri
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