The best replacement for agitation is anxiety.

The best alternatives to agitation are rated as following:
★★★★★  anxiety
★★★★★  stirring
★★★★  restlessness
★★★  psychomotor retardation
★★★  retardation
★★  mixing
★  akathisia
  delirium
  accommodation
  slowing

Your alternative for agitation is not listed? Suggest!
Speaking about agitation, one probably shouldn't forget about dementia.

Other search terms related to agitation and their ratings are:
★★★★★ dementia
★★★ alzheimer's disease
★★★ depression
★ alzheimer's
You have in mind a companion for agitation and it is not yet here? Propose!



Google Trends

Scale is based on the average worldwide traffic of agitation in all years. Click on graph for more.
agitation
anxiety
stirring