The best replacement for advantage ii is advantage multi.

The best alternatives to advantage ii are rated as following:
★★★★★  advantage multi
★★★★★  advantage
★★★★★  frontline
★★★★  frontline plus
★★★  advantix ii
★★★  k9 advantix ii
★★  advantix
★★  advantage 18
★★  comfortis
★  k9 advantix
★  advantage 100
★  advantage multi for cats
  advantix k9
  advantage for cats

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