The best replacement for 8080 is 80.

The best alternatives to 8080 are rated as following:
★★★★★  80
★★★★★  z80
★★★★  6800
★★★★  80 port
★★★  6502
★★  9080
★★  5080
★  9090
★  8008
★  8090
  8060
  7070
  3128

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8080
80
z80