The best replacement for 5.25 is 6.5 speakers.

The best alternatives to 5.25 are rated as following:
★★★★★  6.5 speakers
★★★★  6x8
★★★  5x7
★★★  glock 34
★★★  4x6
★★  3.5 hdd
★★  m&p pro
★★  6x9
★  glock 35
★  4.5
★  4.5 xdm
★  xd tactical
★  6.5
  sole f63
  m p pro
  5.33
  6.5 speaker
  g34
  xdm 3.8
  sole f 63

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5.25
6.5 speakers
6x8