The best replacement for 4l80e is 4l85e.

The best alternatives to 4l80e are rated as following:
★★★★★  4l85e
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★★★★  6l80e
★★★★  allison
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★★★  6l90e
★★★  th350
★★  4l65e
★★  47re
★  2004r
★  powerglide
★  4l80
★  4l70e
★  4l60e identification
★  4l60e transmission
★  nv4500
★  turbo 400
  gear vendor
  allison 1000
  6l80
  47rh

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Speaking about 4l80e, one probably shouldn't forget about 5.3.

Other search terms related to 4l80e and their ratings are:
★★★★★ 5.3
★★★★ cummins
★ 4l60e
th400
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