The best replacement for 375 ruger is 416 ruger.

The best alternatives to 375 ruger are rated as following:
★★★★★  416 ruger
★★★★★  375 h&h
★★★★★  338 win mag
★★★★  375 rum
★★★  338 lapua
★★★  375 h&h mag
★★★  35 whelen
★★★  9.3x62
★★  458 win mag
★★  338 win mag ballistics
★  375 h h
★  h&h
  338
  376 steyr
  375 h and h
  338 rum
  375 ultra
  375 h 26amp 3bh
  338 winchester
  338 wm
  .416 ruger

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375 ruger
416 ruger
375 h&h