The best replacement for 221 fireball is 22 hornet.

The best alternatives to 221 fireball are rated as following:
★★★★★  22 hornet
★★★★  204 ruger
★★★  222
★★★  17 fireball
★★★  222 rem
★★  20 vartarg
★  218 bee
★  17 remington
★  17 hornet
  22 k hornet
  220 swift
  222 remington

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221 fireball
22 hornet
204 ruger