The best replacement for 2.1 is 5.1.

The best alternatives to 2.1 are rated as following:
★★★★★  5.1
★★★  3.1
★★  5.1 sound
★★  2.0
★★  5.1 speakers
★★  2.2
★  5.1 surround sound
★  2.0 speakers
★  soundbar
★  5.1 soundbar
★  2.2 android
★  sound bar
★  5.1 sound bar
★  5.1 for music
  3.0
  pci 2.2
  stereo
  android 2.2
  logitech z-2300
  5.1 computer speakers
  5.1 channel
  7.1
  4.1
  2.3
  4.0
  1.6
  2.2 degree
  5.1 surround
  5.1 system
  1.5
  bose companion 3
  logitech z623
  2.2 froyo
  klipsch 2.1
  ejb 3.0
  caad 10

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2.1
5.1
3.1