The best replacement for 16 bit is 32 bit.

The best alternatives to 16 bit are rated as following:
★★★★★  32 bit
★★★★★  24 bit
★★★  24 bit recording
★★★  32 bit color
★★★  8 bit
★  24 bit sound
★  24 bit audio
★  24 bit color
★  8 bit games
★  8 bit photoshop
★  8 bit audio
★  24 bit flac
  8 bit images
  32 bit float
  24 bit sound card
  32 bit wav
  24 bit music
  12 bit
  32 bit better
  24
  8 bit microcontroller
  32 bit graphics
  8 bit color
  32 bit processor
  8 bit image
  12 bit audio

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Google Trends

Scale is based on the average worldwide traffic of 16 bit in all years. Click on graph for more.
16 bit
32 bit
24 bit