The best replacement for .50 cal is 20mm.

The best alternatives to .50 cal are rated as following:
★★★★★  20mm
★★★★  12.7mm
★★★★  30mm
★★  .50 bmg
★★  .416
★★  .700 nitro express
★  .54 cal muzzleloader
★  .338
★  .408
★  prairie dog

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.50 cal
20mm
12.7mm