The best replacement for .243 is .308.

The best alternatives to .243 are rated as following:
★★★★★  .308
★★★★★  .270
★★★★  .223
★★★  7mm-08
★★★  30-06
★★  .260
★★  6mm
★  25-06
★  .308 ballistics
★  .25-06
★  30 06
★  22 250
  .243 wssm
  6.8 spc
  7mm 08
  .257
  25.06
  .308 trajectory
  .22 250
  .25 06
  30.06
  30 30
  6.8

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.243
.308
.270