The best replacement for zyvox is vancomycin.

The best alternatives to zyvox are rated as following:
★★★★★  vancomycin
★★★  cubicin
★  tygacil
  linezolid

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No companions for zyvox have been suggested so far.
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Google Trends

Scale is based on the average worldwide traffic of zyvox in all years. Click on graph for more.
zyvox
vancomycin
cubicin