The best replacement for wsgi is cgi.

The best alternatives to wsgi are rated as following:
★★★★★  cgi
★★★★  rack
★★★  mod_python
★★  uwsgi
★  fastcgi
★  fastcgi django
★  fcgi
★  mod python

Your alternative for wsgi is not listed? Suggest!
Speaking about wsgi, one probably shouldn't forget about django.

Other search terms related to wsgi and their ratings are:
★★★★★ django
You have in mind a companion for wsgi and it is not yet here? Propose!



Google Trends

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wsgi
cgi
rack