The best replacement for vacuole is vesicle.

The best alternatives to vacuole are rated as following:
★★★★★  vesicle
★★  animal vacuole
★  lysosome
★  vacuole
★  contractile vacuole
★  animal cell vacuole
★  central vacuole
  plant vacuole
  plant cell vacuole

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vacuole
vesicle
animal vacuole