The best replacement for twisted is tornado.

The best alternatives to twisted are rated as following:
★★★★★  tornado
★★★★  braided rope
★★★  gevent
★★  node.js
★★  rolled ankle
★★  asyncio
★★  pretty little liars
★  zeromq
★  nodejs
★  cherrypy
  node
  sprained
  eventlet
  gunicorn
  celery
  oakley ambush

Your alternative for twisted is not listed? Suggest!
Speaking about twisted, one probably shouldn't forget about django.

Other search terms related to twisted and their ratings are:
★★★★★ django
★ sqlalchemy
You have in mind a companion for twisted and it is not yet here? Propose!



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twisted
tornado
braided rope