The best replacement for topaz denoise is noise ninja.

The best alternatives to topaz denoise are rated as following:
★★★★★  noise ninja
★★★★  noiseware
★★★★  neat image
★★  nik dfine
★★  lightroom noise reduction
★  dfine 2.0
  dfine
  imagenomic noiseware
  nik define

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noise ninja
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