The best replacement for tom and jerry is looney tunes.

The best alternatives to tom and jerry are rated as following:
★★★★★  looney tunes
★★★  itchy and scratchy
★★  sylvester and tweety
★★  egg nog
★★  bugs bunny
★  looney toons
★  gumball and darwin
★  tom and jerry
  robot cat and monster jerry
  oggy and the cockroaches
  eggnog
  is you aint my baby

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Speaking about tom and jerry, one probably shouldn't forget about gene kelly.

Other search terms related to tom and jerry and their ratings are:
★★★★★ gene kelly
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tom and jerry
looney tunes
itchy and scratchy