The best replacement for tobramycin is gentamicin.

The best alternatives to tobramycin are rated as following:
★★★★★  gentamicin
★★  vigamox
★★  ofloxacin
★★  terramycin
★★  tobradex
★  erythromycin
★  polytrim
★  moxifloxacin
★  neomycin
★  moxeza
★  amikacin
★  chloramphenicol
  ciprofloxacin
  vancomycin
  tobi
  ceftazidime
  colistin
  polymyxin
  sulfacetamide
  gentamicin sulfate
  tobrex

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tobramycin
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