The best replacement for timbuk2 is chrome.

The best alternatives to timbuk2 are rated as following:
★★★★★  chrome
★★★★  crumpler
★★★  rickshaw
★★★  manhattan portage
★★  tom bihn
★★  tumi
★★  booq
★  osprey
★  patagonia half mass
★  waterfield
  tenba
  chrome bags
  patagonia
  brenthaven
  ogio
  chrome bag

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Google Trends

Scale is based on the average worldwide traffic of timbuk2 in all years. Click on graph for more.
timbuk2
chrome
crumpler