The best replacement for suphp is dso.

The best alternatives to suphp are rated as following:
★★★★★  dso
★★★★  fcgi
★★★★  suexec
★★★  suhosin
★★★  mod_php
★★★  fastcgi
★★  mod_ruid2
★★  php-fpm
★  phpsuexec
★  mod_fcgid
★  mpm-itk

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Google Trends

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suphp
dso
fcgi