The best replacement for spore is seed.

The best alternatives to spore are rated as following:
★★★★★  seed
★★★  gamete
★★  darkspore
★★  sleep powder
★★  sims 3
★★  endospore
★★  dark void
★★  spore galactic adventures
★★  sims
★  capsule
★  spore galactic edition
★  littlebigplanet
★  cyst
  vegetative cell
  galactic edition
  poison powder
  nematodes
  pollen
  grubex
  spore creature creator
  poison heal
  beneficial nematodes
  lbp
  leech seed

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