The best replacement for severe is pervasive.

The best alternatives to severe are rated as following:
★★★★★  pervasive
★★★  serious
★  moderate depression
★  acute
★  mild acne
★  sever
★  profound
★  severer
★  mild preeclampsia
★  mild autism
  stern
  strict
  mild depression
  moderate acne
  mild asthma

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No companions for severe have been suggested so far.
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Google Trends

Scale is based on the average worldwide traffic of severe in all years. Click on graph for more.
severe
pervasive
serious