The best replacement for rune 2h is rune scimitar.

The best alternatives to rune 2h are rated as following:
★★★★★  rune scimitar
★★★★  rune scimmy
★★★★  gravite 2h
★★★  scimitar
★★  granite maul
★  battleaxe

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No companions for rune 2h have been suggested so far.
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rune 2h
rune scimitar
rune scimmy