The best replacement for rme is apogee.

The best alternatives to rme are rated as following:
★★★★★  apogee
★★★★  motu
★★★  rmo
★★★  lynx
★★  focusrite
★★  apollo
★★  metric halo
★  presonus
★  uad
★  universal audio
★  apogee symphony
★  antelope
★  steinberg
  apogee duet
  apogee ensemble
  digi 003
  creamware
  digidesign
  lavry
  pro tools hd
  m audio

Your alternative for rme is not listed? Suggest!
Speaking about rme, one probably shouldn't forget about pro tools 9.

Other search terms related to rme and their ratings are:
★★★★★ pro tools 9
You have in mind a companion for rme and it is not yet here? Propose!



Google Trends

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rme
apogee
motu