The best replacement for red skull is joker.

The best alternatives to red skull are rated as following:
★★★★★  joker
★★★★★  captain america
★★★★  black mask
★★  ra's al ghul
★★  magneto
★★  doctor doom
★★  dr doom
★  baron zemo
★  winter soldier
★  kingpin
★  cobra commander
  thanos

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red skull
joker
captain america