The best replacement for realflow is houdini.

The best alternatives to realflow are rated as following:
★★★★★  houdini
★★★  glu3d
★★  naiad
★★  maya fluids
★★  phoenix fd
★★  money flow
★  monetary flow
★  softimage ice
★  fumefx
★  cinema 4d
  dpit
  nparticles

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Speaking about realflow, one probably shouldn't forget about cinema 4d.

Other search terms related to realflow and their ratings are:
★★★★★ cinema 4d
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Google Trends

Scale is based on the average worldwide traffic of realflow in all years. Click on graph for more.
realflow
houdini
glu3d