The best replacement for r7 250 is 7750.

The best alternatives to r7 250 are rated as following:
★★★★★  7750
★★★★★  7770
★★★  gtx 650
★★★  gt 640
★★★  6670
★★★  r7 240
★★  gtx 750
★★  r7 250x
★★  hd 7770
★  6770
★  hd 7750
  7730

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Speaking about r7 250, one probably shouldn't forget about kaveri.

Other search terms related to r7 250 and their ratings are:
★★★★★ kaveri
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r7 250
7750
7770