The best replacement for quad screen is triple screen.

The best alternatives to quad screen are rated as following:
★★★★★  triple screen
★★★  nt scan
★★  afp
★★  sequential screen
★★  maternit21
★★  harmony test
★  amniocentesis
★  ultrascreen
★  msafp
★  penta screen
★  nuchal translucency
  first trimester screen

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quad screen
triple screen
nt scan