The best replacement for pypanel is tint2.


The best alternatives to pypanel are rated as following:
★★★★★  tint2
★★★  lxpanel

Your alternative for pypanel is not listed? Suggest!
Speaking about pypanel, one probably shouldn't forget about openbox.

Other search terms related to pypanel and their ratings are:

★★★★★ openbox
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Google Trends

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pypanel
tint2
lxpanel