The best replacement for pypanel is tint2.

The best alternatives to pypanel are rated as following:
★★★★★  tint2
★★★  lxpanel

Your alternative for pypanel is not listed? Suggest!
Speaking about pypanel, one probably shouldn't forget about openbox.

Other search terms related to pypanel and their ratings are:
★★★★★ openbox
You have in mind a companion for pypanel and it is not yet here? Propose!



Google Trends

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pypanel
tint2
lxpanel