The best replacement for prettyphoto is fancybox.

The best alternatives to prettyphoto are rated as following:
★★★★★  fancybox
★  colorbox

Your alternative for prettyphoto is not listed? Suggest!
Speaking about prettyphoto, one probably shouldn't forget about nextgen gallery.

Other search terms related to prettyphoto and their ratings are:
★★★★★ nextgen gallery
You have in mind a companion for prettyphoto and it is not yet here? Propose!



Google Trends

Scale is based on the average worldwide traffic of prettyphoto in all years. Click on graph for more.
prettyphoto
fancybox
colorbox