The best replacement for pein is itachi.

The best alternatives to pein are rated as following:
★★★★★  itachi
★★★★  madara
★★★★  naruto
★★★  jiraiya
★★  pain
★★  sasuke
★★  kakashi
★  tobi
★  aizen
★  pain naruto
★  konoha
★  yondaime
★  jiraya
  peen
  naruto video
  fourth hokage
  minato

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Google Trends

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pein
itachi
madara