The best replacement for papain is bromelain.

The best alternatives to papain are rated as following:
★★★★★  bromelain
★★★  pepsin
★★  trypsin
★  papaya

Your alternative for papain is not listed? Suggest!
Speaking about papain, one probably shouldn't forget about bromelain.

Other search terms related to papain and their ratings are:
★★★★★ bromelain
You have in mind a companion for papain and it is not yet here? Propose!



Google Trends

Scale is based on the average worldwide traffic of papain in all years. Click on graph for more.
papain
bromelain
pepsin