The best replacement for panax ginseng is american ginseng.

The best alternatives to panax ginseng are rated as following:
★★★★★  american ginseng
★★★★  siberian ginseng
★★★  red ginseng
★★★  korean ginseng
★★  ginseng
★★  siberian
★★  panax quinquefolius
★  eleuthero
★  white panax ginseng
★  korean red
  ginkgo biloba
  korean red ginseng
  ashwagandha

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american ginseng
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