The best replacement for opteron is xeon.

The best alternatives to opteron are rated as following:
★★★★★  xeon
★★★  athlon
★★★  phenom
★★  x2
★★  fx
★  athlon 64
  itanium
  phenom ii
  xeon e5
  intel xeon
  nehalem
  xeon processor
  amd athlon
  athlon x2
  core 2 quad
  amd x2
  sempron
  phenom ii x6
  g5

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Google Trends

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opteron
xeon
athlon