The best replacement for ophion is lava golem.

The best alternatives to ophion are rated as following:
★★★★★  lava golem
★★★★  shadow imprisoning mirror
★★★  super poly
★★★  breakthrough skill
★★★  infestation infection
★★  abyssmegalo
★★  megalo
★★  metal reflect slime
★  elemental dragons

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ophion
lava golem
shadow imprisoning mirror