The best replacement for nicotine is caffeine.

The best alternatives to nicotine are rated as following:
★★★★★  caffeine
★★★★  tobacco
★★  tar
★★  alcohol
★★  thc
★  heroin
★  tobacco causes cancer
★  caffeine more addictive
★  caffeine which is worse
★  tar worse
★  marijuana
★  smoking
★  cannabis
★  heroin addiction
  nicotinic acid
  arsenic
  cigarette
  caffeine which is more addictive
  cotinine

Your alternative for nicotine is not listed? Suggest!
Speaking about nicotine, one probably shouldn't forget about smoke.

Other search terms related to nicotine and their ratings are:
★★★★★ smoke
★★★★★ caffeine
★★★★ tobacco
★★★★ smoking
★★★ cigarette smoking
★ cigarettes
★ vg
You have in mind a companion for nicotine and it is not yet here? Propose!



Google Trends

Scale is based on the average worldwide traffic of nicotine in all years. Click on graph for more.
nicotine
caffeine
tobacco