The best replacement for mysqli is pdo.

The best alternatives to mysqli are rated as following:
★★★★★  pdo
★★★★★  mysql
★★★  mysql_connect
★★  mysql joomla
★★  mysql php
★★  mysqli_connect
★★  mysqlnd
★  pdo php
★  mysql difference
★  pdo_mysql
★  adodb
  mysql drupal

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Google Trends

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