The best replacement for mule esb is fuse esb.

The best alternatives to mule esb are rated as following:
★★★★★  fuse esb
★★★★★  wso2
★★★★  webmethods
★★★★  jboss esb
★★★  apache camel
★★★  oracle service bus
★★  spring integration
★  talend
★  servicemix

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mule esb
fuse esb
wso2