The best replacement for mesopotamia is egypt.

The best alternatives to mesopotamia are rated as following:
★★★★★  egypt
★★★  ancient egypt
★★  iraq
★  indus valley
★  fertile crescent
★  babylon
  egypt which came first
  egypt civilization
  mesoamerica
  sumer
  egypt geography
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  persia
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  babylonia
  sumeria

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Speaking about mesopotamia, one probably shouldn't forget about fertile crescent.

Other search terms related to mesopotamia and their ratings are:
★★★★★ fertile crescent
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mesopotamia
egypt
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