The best replacement for mercedes e350 is bmw 5 series.

The best alternatives to mercedes e350 are rated as following:
★★★★★  bmw 5 series
★★★★★  audi a6
★★  bmw 530
★★  infiniti q50
★★  bmw 535i
★★  bmw 535
★  audi a7
★  lexus gs350
★  cadillac xts
★  bmw 530i
★  lexus es350
★  lexus gs 350
★  audi a5
  bmw 528
  lexus es 350
  hyundai genesis
  jaguar xf
  bmw 528 535
  bmw 530xi
  cadillac dts

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mercedes e350
bmw 5 series
audi a6